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. 2016 Feb 17;173(6):1005–1017. doi: 10.1111/bph.13404

Figure 3.

Figure 3

Concentration–response curves to BK in endothelium‐intact mesenteric arteries of rats treated with placebo (A), 48 h (B) or 72 h (C) of continuous i.v. infusion of serelaxin. Responses to BK (A–C) were evaluated either in the absence (control) or in the presence of Indo (1 μmol·L−1, non‐selective COX inhibitor), U51605 (1 μmol·L−1, PGI2S inhibitor), SC560 (1 μmol·L−1, COX1 inhibitor) or NS398 (1 μmol·L−1, COX2 inhibitor). Mesenteric artery sensitivity (D, pEC50) to BK following 72 h of serelaxin treatment. Levels of BK (1 μmol·L−1)‐induced 6‐keto PGF1α in endothelium‐intact mesenteric arteries of rats treated with placebo, 48 h (E) or 72 h (F) of continuous i.v. infusion of serelaxin. n = 5–9 per group. * P < 0.05; pEC50 significantly different from control; one‐way anova, Dunnett's post hoc test. # P < 0.05; significantly different from placebo; unpaired Student's t‐test.