Table 2.
Stimulation and monitoring of treatment cycles by year.
| Year | Cycles (n) (stimulated or monitored) | Stimulation protocol (Pn x doses) | IU of HCG (Hours between HCG and LOR) [Day of LOR] | Urine monitoring | Serum monitoring | Cancelled LORa (n) | LOR converted to ITI/AIbor outcome unrecorded (n) | LOR with documented egg recovery (n) (% of stimulated cycles started) | Eggs (n) | Mean no. of eggs/cycle (range) |
|---|---|---|---|---|---|---|---|---|---|---|
| 1969 | 58 | P2 x 1 or 2; then from July P3/P2 on alternate days; then P3 x 4 or x 3 | 3000–12,000; 5000 from Sept (28.75–29.50) [D10–12] | 24-h TE, alternate days from D6 – D8 + occasional PD | NR | None | None | 48 (83) | 136 | 2.3 (1–8) |
| 1970 | 62 | P4 x 3 | 5000 (Jan–Feb: 29.5–30.0; Mar–Dec: 32.0–33.5) [D10–D12] | 24-h TE + PD, every 2 days + luteal phase in some case. Results plotted on graphs | NR | None | 3 | 55 (89) | 274 | 5.0 (1–12) |
| 1971 | 41 | P4 x 3 | 5000 (33.5–36.0) | 24-h urines: TE, PD, every 3 – 4 days approx + PT in March/April | NR | None | 1 | 36 (88) | 175 | 4.9 (1–12) |
| 1972 | 41 | P4 x 3, P3 x 4, P5 x 3, P5, P2 P2 | 5000, 8000 in Sept (31.0–33.5) | 24-h urines – TE, PD every 2 days + post--Lap | July: occasional Lap-day TE, Prl; April–June: Blood groups, both partners | 1 | None | 39 (95) | 187 | 4.8 (1–11) |
| 1973 | 44 | P3 x 4, P2 x 4 (18 cases) CL/Pregnyl (17 cases); NC/Pregnyl (9 cases) | 5000 (3) 8000 (15) 5000 (2) 10,000 (2) 8000 (13) 5000 (32.5–33.0) | 24-h urines: TE, PD every 2 days, + post--LapCL cases – daily from March onwards, LH and FSH from March | Occasional single TE, FSH, LH, Prl (not all cases, not all tests) | 6 | 12 | 25 (57) | 86 | 3.4 (1–8) |
| 1974 | 37 + 3C | NC + Pregnyl (25 cases); NC + MRC LH (2 cases); P3 x 4 or P4 x 3 (11 cases) | 5000 (32.5–33.0) | Daily 24-h urines –TE, PD, LH | Occasional single TE, FSH, LH, Prl (not all cases, not all tests) | 2 | None | 28 + 2c (75) | 85 + 4c | 2.9 (1–6) |
| 1975 | 36 | NC + Pregnyl (6 cases) P3 x 4 or P4 x 3 (30 cases) | 5000 (NR) | Daily 24-h urines: TE, PD, LH – + PT from August | HCG from Lap day in Sept. Occasional luteal + Prl, LH from Sept. | 2 | None | 33 (92) | 117 | 3.5 (1–7) |
| 1976 | 55 + 1c | P4 x 4, P5 x 3, P5 x 4, P5, P2, P2 | 5000, 3000 (7 cases) (32 where recorded) | Daily 24-h TE, PD, LH, + luteal phase | From Sept: E, FSH, P, Prl, 1–6 samples per cycle (not all cases, not all tests) | 4 | 3 ovaries not accessible (P212, 224, 232) | 44 + 1c (80) | 147 + 2C | 3.3 (1–9) |
| 1977 | 43 | P5 x 3 + Parlodel; CL/HMG (2 ), NC/Hi-Gonavis (3 ) | 5000 2 cases MRC LH (32–33) | 24-h urines: TE, PD, LH + luteal phase. From Nov: Hi-Gonavis | Every 2–3 days: E, P, FSH, LH, HCG, Prl | 10 | None | 28 (65) | 97 | 3.5 (1–9) |
| 1978 | 78 + 2c | NC/Hi-Gonavis (78) [+ P5 x 4 in 2 cases for sterilization] | 5000 | Daily 24-h E, PD, LH; 3-h LH from D5 – D7 until surge detected | E, P, LH, FSH, Prl every 2 days + post-ET | 13 | 2 ovaries not accessible (P232, 213) | 52 + 2c (68) | 57 + 4c | 1.2 (1–2) |
| Total | 495 + 6c | – | – | – | – | 38 | 22 | 388 + 5c (78) | 1371 | 3.6 (1–12) |
AI = artificial insemination; CL = Clomid; D = day; E = estrogen; ET = embryo transfer; FSH = follicle-stimulating hormone; HCG = human chorionic gonadotrophin; HMG = human menopausal gonadotropin; ITI = intra-tubal insemination; Lap = laparoscopy; LOR = laparoscopic oocyte retrieval; NC = natural cycle ; NR = not recorded; TE = total estrogen; Pn = number of Pergonal ampoules; P = progesterone; PD = pregnandiol ; Prl = prolactin; PT = pregnanetriol.
a
See Table 3 (Elder and Johnson, 2015b).
b
See Table 4 (Elder and Johnson, 2015b).
c
Cases for laparoscopic sterilization (see Table 1, Elder and Johnson, 2015b).