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. 2016 Oct 12;7(51):84314–84325. doi: 10.18632/oncotarget.12604

Figure 4. Ablation of BMP9 reduces the growth of primary PanNETs.

Figure 4

(A) qRT-PCR expression levels of ligands BMP10 and GDF5, and receptors ALK1, Endoglin and ALK5 in whole PanNET tumors from RIP1-TAg2 wildtype, and Gdf2 knockout mice at 12 weeks. (B–D) Total PanNET tumor volume (B), number of tumors (C) and number of angiogenic islets (D) from RIP1-TAg2 mice at 12 weeks. (E–J) Expression correlation of GDF2 and BMP10 against ACVRL1, ENG and an endothelial metagene (CD34, CDH5, PECAM1), (E–I), and of GDF2 against BMP10 (J) from a human dataset of pancreatic neuroendocrine tumors and metastases (K–N) Expression correlation of Gdf2 against Acvrl1, Eng, an endothelial metagene (CD34, CDH5, PECAM1), and Bmp10 (K-N) from a mouse dataset of pancreatic neuroendocrine RIP1-TAg2 islets, tumors and metastases Data are mean ± SEM. *P < 0.05; **P < 0.01; ***P < 0.001 vs. Wildtype with Student's t-test.