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. 2017 Mar 7;17:179. doi: 10.1186/s12885-017-3153-4

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 7 — Schematic diagram of the mechanism for CPA enhancement of TRAIL induced apoptosis in prostate cancer cells. CPA treatment induces CHOP protein expression via ER stress response pathways. CHOP protein binds to the promoter region of DR5 gene and up-regulates DR5 mRNA and protein expression. Up-regulated DR5 protein arguments TRAIL induced Bid-dependent apoptotic pathways in prostate cancer cells