Table 1.
HLA-DRβ1 categorized according to 3rd HVR sequences, DRB1 alleles encoding each sequence, and associated charges
| 3rd HVR | aa 67–74 | DRB1 alleles | Charge |
|---|---|---|---|
| 1 | LLEQRRAA | 01:01, 01:02, 01:08, 04:04, 04:05, 04:08, 14:02, 14:06, 14:20 | +1 |
| 2 | I--DE--- | 01:03, 04:02, 11:02, 13:01, 13:02, 13:04, 13:28 | −2 |
| 3 | ---R---- | 10:01 | +2 |
| 4 | I---A--- | 15:01, 15:02, 15:03 | 0 |
| 5 | F--D---- | 11:01, 11:04, 12:02, 13:05, 16:01 | 0 |
| 6 | ---D---- | 16:02 | 0 |
| 7 | ----K--- | 04:01 | +1 |
| 8 | -------E | 04:03, 04:07 | 0 |
| 9 | I--D--GQ | 07:01 | 0 |
| 10 | F--R---E | 09:01 | +1 |
| 11 | F--D---L | 08:01, 08:02, 08:04, 08:06 | 0 |
| 12 | I--D---L | 08:03 | 0 |
| 13 | F--DE--- | 11:03 | −2 |
| 14 | I--D---- | 12:01 | 0 |
| 15 | ----K-GR | 03:01 | +2 |
| 16 | I--DK--- | 13:03 | 0 |
| 17 | ---R---E | 14:01 | +1 |
Summary is for all 3rd HVR sequences and DRB1 alleles observed in at least one study subject
3rd HVR third hypervariable region, aa amino acids