Table 2.
Allele frequencies classified according to the third hypervariable region in controls and SSc patients
| Controls | SSc | |||
|---|---|---|---|---|
| HVR region | n (%) | n (%) | p value | OR (95% CI) |
| 1 | 68 (18.4) | 34 (14.0) | 0.160 | 0.73 (0.46–1.14) |
| 2 | 44 (11.9) | 24 (9.9) | 0.447 | 0.82 (0.48–1.38) |
| 3 | 3 (0.8) | 1 (0.4) | ||
| 4 | 58 (15.7) | 21 (8.7) | 0.012 | 0.51 (0.30–0.87) |
| 5 | 36 (9.7) | 43 (17.8) | 0.004§ | 2.00 (1.25–3.23) |
| 6 | 0 (0.0) | 1 (0.4) | – | |
| 7 | 34 (9.2) | 25 (10.3) | 0.640 | 1.14 (0.66–1.96) |
| 8 | 4 (1.1) | 8 (3.3) | ||
| 9 | 48 (13.0) | 29 (12.0) | 0.718 | 0.91 (0.56–1.49) |
| 10 | 4 (1.1) | 2 (0.8) | ||
| 11 | 8 (2.1) | 16 (6.6) | 0.006# | 3.20 (1.35–7.61) |
| 12 | 1 (0.3) | 0 (0.0) | – | |
| 13 | 5 (1.3) | 6 (2.5) | ||
| 14 | 6 (1.6) | 4 (1.7) | ||
| 15 | 41 (11.1) | 26 (10.7) | 0.896 | 0.97 (0.57–1.63) |
| 16 | 3 (0.8) | 0 (0.0) | – | |
| 17 | 7 (1.9) | 2 (0.8) | ||
| All | 370 | 242 |
Third HVR overall distribution, SSc patients versus controls, p = 0.007
§ p c = 0.032
# p c = 0.048
SSc systemic sclerosis, HVR hypervariable region, OR odds ratio, CI confidence interval, pc p value corrected for multiple comparisons