Table 3.
DQβ1 hypervariable region and charge, amino acids 70–77a
| Amino acid position | Overall charge | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Allele | 70 | 71 | 72 | 73 | 74 | 75 | 76 | 77 | |
| 05:01/2/3 | G | A | R | A | S | V | D | R | +1 |
| 06:01/4/9/11, 03:01/2/3 | R | T | – | – | E | – | – | T | 0 |
| 06:02/3/11/16 | – | T | – | – | E | L | – | T | −1 |
| 02:01/2 | R | K | – | – | A | – | – | – | +3b |
| 04:01/2 | E | D | – | – | – | – | – | T | −2 |
aAmino acids that differ from the consensus (alleles on the first line) by charge are presented in bold. Sequences encoded by uncommon alleles not present in our study populations are not included
bAmong SSc patients with DQβ1 + 3 charge, eight were inherited paternally and 31 inherited maternally (p corrected = 0.001)