Table 4.
DQα1 hypervariable region and charge, amino acids 47–56a
| Amino acid position | Overall chargeb | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Allele | 47 | 48 | 49 | 50 | 51 | 52 | 53 | 54 | 55 | 56 | |
| 01:01/2/3/4/5 | R | W | P | E | F | S | K | F | G | G | +1 |
| 02:01 | K | – | – | L | – | H | R | – | R | – | +4 |
| 03:01/2/3 | Q | – | – | L | – | R | R | – | R | R | +4 |
| 04:01 | C | – | – | V | – | R | Q | – | R | – | +2 |
| 05:01/3/5 | C | – | – | V | – | R | Q | – | R | – | +2 |
| 06:01 | C | – | – | V | – | R | Q | – | R | – | +2 |
aAmino acids that differ from the consensus (alleles on the first line) by charge are presented in bold. Sequences encoded by uncommon alleles not present in our study populations are not included
bParental inheritance was not skewed according to any DQα1 charge category. Similarly, results were not skewed if alternatively considered to extend to include a polymorphism at DQα1 amino acid 64