Table 3.
Analysis of features for false negative (FN) predictions of Provean, PolyPhen-2 and Mitoclass.1 in validation dataset
| AA substitution (polypeptide) | FN | CI | F1 | F2 | F3 |
|---|---|---|---|---|---|
| p.A132T (p.MT-ND1) | PolyPhen-2 | 72.82 | 123.98 | 0.30 | 12.59 |
| p.L289M (p.MT-ND1) | Provean | 29.72 | 78.64 | 1.99 | 16.07 |
| p.S34P (p.MT-ND3) | PolyPhen-2 and Provean | 10.15 | 60.53 | 0.34 | 5.23 |
| p.V65A (p.MT-ND4L) | Mitoclass.1 | 24.72 | 103 | 35.06 | 6.78 |
CI refers to conservation index for each position. F1, F2 and F3 refer to the numerical values of the three attributes considered for Mitoclass.1 classifier