Table 3.
Diagnosis of WHO Group I PAH by risk stratification using the screening algorithm
| No increased probabilitya |
Low probability of PAHa | Moderate probability of PAHa | High probability of PAHa | Missing sPAP | Total with PAH, n | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Review number | Screened, n | Normal TTE, n | RHC, n |
PAH, n |
Moderate TTE, n | RHC, n |
PAH, n |
High suspicion TTE, n | RHC, n |
No. with PAH | High probability TTE, n | RHC, n |
PAH, n |
Positive screenc, n |
RHC, n | PAH, n |
|
| 1st screen | 1363 | 470 | 19 | 4 | 358 | 38 | 11 | 121 | 36 | 25 | 101 | 83 | 72 | 313 | 24 | 10 | 122 (8.9%) |
| 2nd screen | 896 | 355 | 6 | 2 | 229 | 5 | 3 | 78 | 10 | 4 | 32 | 11 | 5 | 202 | 8 | 3 | 17 (1.9%) |
| 3rd screen | 679 | 272 | 0 | 0 | 167 | 4 | 1 | 65 | 5 | 3 | 20 | 7 | 6 | 155 | 3 | 1 | 11 (1.6%) |
| 4th screen | 482 | 199 | 0 | 0 | 125 | 3 | 0 | 42 | 7 | 2 | 13 | 5 | 3 | 103 | 1 | 0 | 5 (1.0%) |
| 5th screen | 361 | 149 | 0 | 0 | 104 | 0 | 0 | 25 | 1 | 1 | 9 | 4 | 1 | 74 | 1 | 0 | 2 (0.6%) |
| 6th screen | 235 | 91 | 0 | 0 | 72 | 1 | 1 | 25 | 1 | 1 | 6 | 0 | 0 | 41 | 0 | 0 | 2 (0.9%) |
| 7th screen | 162 | 66 | 0 | 0 | 48 | 0 | 0 | 14 | 0 | 0 | 3 | 0 | 0 | 31 | 1 | 0 | 0 (0.0%) |
| 8th screen | 104 | 48 | 0 | 0 | 27 | 1 | 1 | 10 | 0 | 0 | 1 | 0 | 0 | 18 | 0 | 0 | 0 (0.0%) |
| 9th screen | 43 | 20 | 0 | 0 | 11 | 1 | 1 | 6 | 0 | 0 | 1 | 0 | 0 | 5 | 0 | 0 | 1 (2.3%) |
| 10th screen | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 (0.0%) |
| Total | 4326 | 1670 | 25b (1.5%) | 6a (24%) | 1142 | 53b (4.6%) | 17a (32.7%) | 386 | 60b (15.5%) | 36a (60%) | 186 | 110b (59%) | 87a (79.1%) | 942 | 38b (4%) | 14a (36.8%) | 160 (11.7%) |
aProbability of pulmonary arterial hypertension (PAH): no increased probability of PAH was indicated by systolic pulmonary arterial pressure (sPAP) <30 and diffusing capacity of the lung for carbon monoxide corrected for haemoglobin (DLCO) >50%, low probability of PAH was indicated by 30 ≤ sPAP <40 mmHg with normal forced vital capacity (FVC) and high-resolution computed tomography (HRCT), moderate probability of PAH was 40 ≤ sPAP <50 mmHg OR DLCO ≤50% and FVC <85% or annual fall in DLCO ≥20% or unexplained dyspnea and high probability of PAH was indicated by sPAP ≥50 mmHg.
bPercentage of patients who were detected by transthoracic echocardiogram (TTE) to be in a risk category and underwent right-heart catheterisation (RHC)
cPercentage of patients who underwent RHC and were diagnosed with World Health Organisation (WHO) Group I PAH