Table 3.

Associations of arsenic exposure metrics with LINE-1 methylation levels

As-exposure	Dependent variable LINE-1 methylation (%)
	All subjectsa		Malesb		Femalesc
	Unadjusted	Adjusted	Unadjusted	Adjusted	Unadjusted	Adjusted
Water As
R2	0.033	0.057	0.003	0.018	0.079	0.085
ΔR2	0.024		0.015		0.006
95% CI	−0.241,−0.043	−0.238,−0.038	−0.161, 0.085	−0.178,0.076	−0.410,−0.088	−0.407,−0.081
p-value	<0.01	<0.01	0.539	0.428	<0.01	<0.01
Hair As
R2	0.019	0.045	0.003	0.019	0.043	0.053
ΔR2	0.009		0.016		0.010
95% CI	−0.378,−0.014	−0.382,−0.014	−0.282,0.150	−0.318,0.129	−0.662,−0.038	−0.664,−0.037
p-value	<0.05	<0.05	0.545	0.406	<0.05	<0.05
Nail As
R2	0.054	0.079	0.016	0.031	0.100	0.106
ΔR2	0.025		0.015		0.006
95% CI	−0.595,−0.179	−0.591,−0.175	−0.469,0.079	−0.490,0.066	−0.862,−0.236	−0.858,−0.224
p-value	<0.001	<0.001	0.162	0.134	<0.01	<0.01

Log-transformed values of arsenic concentrations were used

^aAdjusted for age, sex, BMI and smoking status

^bAdjusted for age, BMI and smoking status

^cAdjusted for age and BMI