Table 2.
Exposure to angiotensin II receptor blockers (ARB), angiotensin-converting enzyme (ACE) inhibitors and their relative risk for acute pancreatitis estimated by odds ratio (OR) with 95% confidence intervals (CI)
| Exposure | Controls | Cases | Model 1a | Model 2b | Model 3c |
|---|---|---|---|---|---|
| N (%) | N (%) | OR 95% CI | OR 95% CI | OR 95% CI | |
| Total | 61,637 (100) | 6,161 (100) | |||
| ARB | |||||
| Never use | 56,542 (92) | 5,571 (90) | 1 (reference) | 1 (reference) | 1 (reference) |
| Current use | 4,715 (8) | 548 (9) | 1 · 18 (1 · 08–1 · 30) | 0 · 82 (0 · 74–0 · 90) | 0 · 77 (0 · 69–0 · 86) |
| Past use | 380 (1) | 42 (1) | 1 · 13 (0 · 82–1 · 55) | 0 · 77 (0 · 74–0 · 90) | 0 · 70 (0 · 49–1 · 01) |
| ACE-inhibitors | |||||
| Never use | 55,073 (89) | 5,080 (82) | 1 (reference) | 1 (reference) | 1 (reference) |
| Current use | 6,067 (10) | 987 (16) | 1 · 82 (1 · 69–1 · 96) | 1 · 16 (1 · 07–1 · 26) | 1 · 11 (1 · 01–1 · 21) |
| Past use | 497 (1) | 94 (2) | 2 · 11 (1 · 69–2 · 63) | 1 · 37 (1 · 09–1 · 72) | 1 · 24 (0 · 95–1 · 60) |
aAdjusting for sex, age and calendar year. bAs Model 1 + presence of cardiovascular disorder
cAdjusting for sex, age, calendar year, education, alcohol related disease, gallstone disease, chronic obstructive pulmonary disease, diabetes, cardiovascular disorder, and number of distinct medications, Angiotensin-converting enzyme (ACE)-inhibitors and ARB