Table 3.
Exposure to angiotensin receptor blockers (ARB) and severity of acute pancreatitis, estimated by odds ratios (OR) with 95% confidence intervals (CI)
| Exposure | Controls | Mild acute pancreatitis | Moderate acute pancreatitis | Severe acute pancreatitis |
|---|---|---|---|---|
| N (%) | N (%) | N (%) | N (%) | |
| Total, n (%) | 61,637 (100) | 2,783 (100) | 1,542 (100) | 1,814 (100) |
| ARB | 56,542 (92) | 2,514 (90) | 1,403 (91) | 1,632 (90) |
| Never use | ||||
| Current use | 4,715 (8) | 249 (9) | 131 (8.5) | 168 (9) |
| Model 1 OR (95 % CI) | 1 (Reference) | 1 · 25 (1 · 10–1 · 44) | 1 · 08 (0 · 90–1 · 30) | 1 · 18 (1 · 00–1 · 39) |
| Model 2 (OR (95 % CI) | 0 · 86 (0 · 75–0 · 99) | 0 · 73 (0 · 61–0 · 88) | 0 · 76 (0 · 64–0 · 89) | |
| Model 3 OR (95 % CI) | 0 · 81 (0 · 70–0 · 94) | 0 · 71 (0 · 58–0 · 87) | 0 · 71 (0 · 59–0 · 85) | |
| Past use | 380 (1) | 20 (0.5) | 8 (0.5) | 14 (1) |
| Model 1 OR (95 % CI) | 1 (Reference) | 1 · 24 (0 · 79–1 · 95) | 0 · 82 (0 · 41–1 · 66) | 1 · 23 (0 · 72–2 · 10) |
| Model 2 OR (95 % CI) | 0 · 85 (0 · 54–1 · 33) | 0.56 (0.28–1.13) | 0 · 79 (0 · 49–1 · 35) | |
| Model 3 OR (95 % CI) | 0 · 75 (0 · 46–1 · 22) | 0.53 (0 · 26–1 · 08) | 0 · 75 (0 · 42–1 · 29) |
1) Adjusting for sex, age and calendar year
2) Adjusting for sex, age, calendar year and presence of cardiovascular disorder
3) Adjusting for sex, age, calendar year, education, chronic obstructive pulmonary disease, diabetes, alcohol related disease, cardiovascular disorder, and number of distinct medications