Table 3.
Association between acute kidney injury and the polymorphisms studied in 653 patients with sepsis (additive genetic model)
| Univariate | Multivariate | |||||||
|---|---|---|---|---|---|---|---|---|
| SNP | Chr | Base-pair position | Gene and alleles (major/minor) | Minor allele frequencya | Odds ratio (95% CI) |
P value | Odds ratio (95% CI)b |
P value |
| rs625145 | 11 | 116857220 | SIK3 A/T | 0.20/0.21 | 0.88 (0.67–1.17) | 0.38 | 0.93 (0.68–1.25) | 0.62 |
| rs1955656 | 14 | 94579038 | SERPINA5 G/A | 0.10/0.12 | 0.77 (0.53–1.10) | 0.15 | 0.75 (0.51–1.10) | 0.14 |
| rs2093266 | 14 | 94566450 | SERPINA4 G/A | 0.10/0.12 | 0.77 (0.53–1.10) | 0.15 | 0.75 (0.51–1.10) | 0.14 |
| rs8094315 | 18 | 63268814 | BCL2 A/G | 0.24/0.22 | 1.10 (0.85–1.43) | 0.48 | 1.08 (0.81–1.43) | 0.61 |
| rs12457893 | 18 | 63258928 | BCL2 A/C | 0.37/0.37 | 1.02 (0.81–1.29) | 0.87 | 1.06 (0.82–1.36) | 0.67 |
aPatients/controls. bAdjusted for age, body mass index, diabetes mellitus, mechanical ventilation, minimum platelet count, use of non-steroidal anti-inflammatory drugs as daily medication, chronic pulmonary obstructive disease, administration of contrast medium prior to ICU admission, administration of colloids prior to ICU admission, simplified acute physiology score II without age or renal components, operative admission, and source of infection. SNP single nucleotide polymorphism, Chr chromosome