Table 1.
List of SNPs (correlated < 0.9) associated with cannabis initiation (p < 10−5), and proxies where used
| rs number | Chromosome | Nearest gene (within 100000 base pairs) | β (s.e.) cannabis initiation | β (s.e.) schizophrenia | Proxy | r2 for proxy |
|---|---|---|---|---|---|---|
| rs7675351 | 4 | SCOC | 0.15 (0.03) | 0.00 (0.02) | ||
| rs7700636 | 5 | NR3C1 | 0.15 (0.03) | 0.01 (0.01) | ||
| rs17237367 | 15 | RORA | 0.12 (0.03) | 0.01 (0.01) | ||
| rs4984458a | 15 | – | 0.10 (0.02) | −0.01 (0.01) | rs12906344 | 1.000 |
| rs4984460 | 15 | – | 0.12 (0.03) | −0.01 (0.01) | ||
| rs3738226 | 1 | RCSD1 | 0.10 (0.02) | 0.00 (0.01) | ||
| rs74944517a | 2 | LOC129656 | 0.29 (0.06) | 0.02 (0.02) | rs1526674 | 1.000 |
| rs2326313a | 3 | CADM2 | 0.10 (0.02) | −0.01 (0.01) | rs9819830 | 1.000 |
| rs6840574 | 4 | – | 0.15 (0.03) | 0.01 (0.01) | ||
| rs1554927 | 8 | CALB1 | 0.10 (0.02) | 0.02 (0.01) | ||
| rs12789616 | 11 | NCAM1 | 0.09 (0.02) | 0.02 (0.01) | ||
| rs8041045a | 15 | – | 0.10 (0.02) | 0.00 (0.01) | rs12439562 | 0.971 |
| rs73067624a | 1 | KCNT2 | 0.18 (0.04) | 0.02 (0.02) | ||
| rs12518098a | 5 | ZSWIM6 | 0.10 (0.02) | 0.02 (0.01) | ||
| rs353253a | 5 | PCYOX1L | 0.11 (0.03) | −0.01 (0.01) | ||
| rs8102250a | 19 | CRX | 0.13 (0.03) | 0.01 (0.01) | ||
| rs113019398a | 20 | LINC00687 | 0.17 (0.04) | −0.03 (0.02) | ||
| rs2033867a | 2 | SP9 | 0.24 (0.05) | 0.05 (0.02) | ||
| rs13063578a | 3 | SETD2 | 0.11 (0.02) | 0.02 (0.01) | ||
| rs7107987a | 11 | CHID1 | 0.27 (0.06) | 0.01 (0.01) | ||
| rs12313672a | 12 | RNA5SP356 | 0.14 (0.03) | 0.02 (0.01) |
a
Single nucleotide polymorphisms (SNPs) not in education/height genome-wide association study.