Table 3.

MR-Egger regression analyses showing intercept and causal estimate values for associations between cannabis initiation and various outcomes and schizophrenia and cannabis initiation

Exposure	Outcome		ORa	95% CI	P	N SNPs
Cannabis initiation	Schizophrenia (binary outcome)	Intercept	0.99b	0.98–1.01	0.50	21
		Causal estimate	1.01b	0.93–1.10	0.815
Cannabis initiation	Education (years)	Intercept	0.99b	0.99–1.00	0.182	12
		Causal estimate	0.94b	0.88–1.00	0.062
Cannabis initiation	Height (z score)	Intercept	0.99b	0.98–1.00	0.093	12
		Causal estimate	0.95b	0.88–1.01	0.095
Cannabis initiation	Schizophrenia (binary outcome)	Intercept	1.00b	0.97–1.03	0.801	12c
		Causal estimate	1.01b	0.88–1.17	0.854
Schizophrenia	Cannabis initiation (binary outcome)	Intercept	1.00	0.98–1.01	0.524	107
		Causal estimate	1.17	0.96–1.43	0.128

OR, Odds ratio; CI, confidence interval; SNP, single nucleotide polymorphism.

^aPer doubling in odds of exposure.

^bCorrelated likelihood method used.

^cRestricted number of SNPs to be comparable to positive/negative control analyses.