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. 2016 Oct 7;150(1):115–126. doi: 10.1111/imm.12672

Figure 1.

Figure 1

Glucocorticoid treatment reduces disease clinical score and constrains the pool of circulating leucocytes. C57BL/6 mice were exposed to dextran sulphate sodium (DSS) 3% and treated daily with dexamethasone as depicted in the grey rectangle. On day 6 mice were killed to obtain blood samples. (a) Clinical disease score. (b) Percentage of weight change. (c) Total leucocytes/ml. Frequencies of (d) lymphocytes, (e) monocytes and (f) neutrophils are expressed as percentage of cells. Absolute values of lymphocytes (g), monocytes (h) and neutrophils (i), are expressed as number of cells/ml. DSS: C57BL/6 mice exposed to DSS; DSS+GC: C57BL/6 mice exposed to DSS and treated with glucocorticoids. The dashed lines correspond to the group of C57BL/6 control mice not exposed to DSS. These results are representative of three independent experiments with five mice/group. Data were analysed using one‐tailed unpaired t‐tests in (c), (d), (f), (g) and Mann–Whitney one‐tailed tests in (a), (b), (e) (h), (i). *P < 0·05.