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. 2016 Oct 7;150(1):115–126. doi: 10.1111/imm.12672

Figure 3.

Figure 3

Glucocorticoid induces peroxisome proliferator‐activated receptor (PPAR) expression and attenuates inflammation during experimental colitis. C57BL/6 mice were exposed to dextran sulphate sodium (DSS) 3% and treated with dexamethasone as described in the Material and methods. The colon was collected on the 6th day of colitis for real‐time PCR assay. In (a) relative expression of interferon‐γ (IFN‐γ), (b) interleukin‐1β (IL‐1β), (c) PPAR) ‐α and (d) PPAR‐γ (d). (e) Concentration of FITC‐Dextran expressed as μg/ml. (f) Post‐mortem score. DSS: C57BL/6 mice exposed to DSS; DSS+GC: C57BL/6 mice exposed to DSS and treated with glucocorticoids. The dashed lines correspond to the group of C57BL/6 control mice not exposed to DSS. These results are representative of three independent experiments with five mice/group. Data were analysed using one‐tailed unpaired t‐tests in (c) and Mann–Whitney one‐tailed tests in (a), (b), (d), (e), (f). *P < 0·05.