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. 2017 Mar 8;7:43662. doi: 10.1038/srep43662

Figure 3. Transient and small alterations of gut microbial structure by low-dose penicillin.

Figure 3

(a) Study design: Three-week weanling male C57BL/6 mice were treated with low-dose penicillin, metronidazole or regular water as control, respectively. Fecal samples were collected on baseline, week 2 and 3 (n = 5/group). (b,c) Chao1 richness estimator and Shannon diversity index of gut microbiota from samples collected on week 2 (b) and week 3 (c) after rarefying the sequencing depth. (d) Principle component analysis (PCA) plot of week-2 samples along principle component (PC) 1 and 2, which explained 27.55% and 15.07% of the total variance, respectively. (e) PCA plot of week-3 samples along PC1 and PC3, explaining 37.71% and 8.38% of the variance. (f–h) Venn diagrams showing shared OTUs among groups of different treatment and sample collecting time. (i,j) Microbial composition at phylum level (i) and gunus level (j). Data are expressed as mean ± SEM. *P < 0.05, **P < 0.01, NS: not significant, one-way ANOVA.