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. Author manuscript; available in PMC: 2017 Mar 8.
Published in final edited form as: Receptors Clin Investig. 2017 Jan 30;4(1):e1500.

Figure 1. Superantigens induce a cytokine storm by binding to B7-2 and CD28, enhancing costimulatory axis formation.

Figure 1

Two SEB molecules bind, through their accessible β-strand/hinge/α-helix domain (magenta spheres), B7-2 and CD28 in their extracellular domains at the homodimer interfaces (outlined in magenta), thereby potently enhancing B7-2/CD28 engagement and inflammatory signaling. For clarity, simultaneous engagement of TCR and MHC-II molecule by SEB and the second monomer in the CD28 dimer were omitted.