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. 2016 Apr 27;17(1):35–45. doi: 10.3727/105221616X691578

Figure 2.

Figure 2

Improved liver regeneration after APAP overdose in ILK KO mice. (A) Representative photomicrographs showing Ki-67 immunofluorescence performed on frozen liver sections of WT or ILK KO mice treated with 300 mg/kg APAP. (B) Western blot analysis of proliferating cell nuclear antigen (PCNA), cyclin D1, CDK4, and phospho-Rb using total cell extract of liver of WT or ILK KO mice treated with 300 mg/kg APAP. All samples were collected at 0, 6, and 24 h after APAP treatment. Densitometric analysis showing quantification of protein expression of (C) PCNA, (D) cyclin D1, (E) CDK4, and (F) phospho-Rb relative to actin as loading control. Significant difference between groups at *p < 0.05, **p < 0.01, and ***p < 0.001.