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. Author manuscript; available in PMC: 2018 Mar 1.
Published in final edited form as: J Cardiovasc Pharmacol. 2017 Mar;69(3):129–139. doi: 10.1097/FJC.0000000000000458

FIG 10.

FIG 10

Dose Response to clonidine of supine and standing systolic and diastolic blood pressures and plasma renin activity in refractory hypertensive patients treated with minoxidil-BB. Maximum lowering of blood pressures occurred at 0.4 mg/day as with suppression of plasma NE. However, with 0.8 mg/day higher plasma renin activities and blood pressures were associated with diuresis-weight loss; these fascinating mechanisms are discussed in the text. (Reprinted from the Journal of Cardiovascular Pharmacology, HC Mitchell and WA Pettinger, Dose Response of Clonidin on Plasma Catecholamines in the Hypernoradrenergic State Associated with Vasodilator beta-blocker Therapy, vol 3, page 651. Copyright 1981 Wolters Kluwer)