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Design of the first NIH supported, randomized, long term clinical trial attempting to establish a goal blood pressure to optimally conserve kidney function in previously refractory hypertensive patients with advanced nephrosclerosis. (Reprinted with permission from Hypertension, William A. Pettinger et al, Long-term Improvement in Renal Function after Short-term Strict Blood Pressure Control in Hypertensive Nephrosclerosis, vol 13, page 767. Copyright 1989 Wolters Kluwer)
