Table 3.
Association between LV geometric pattern and upper quartile of log-WMHV.
| Concentric remodeling | Eccentric hypertrophy | Concentric hypertrophy | ||||
|---|---|---|---|---|---|---|
| Unadjusted OR (95% CI) |
Adjusted* OR (95% CI) |
Unadjusted OR (95% CI) |
Adjusted* OR (95% CI) |
Unadjusted OR (95% CI) |
Adjusted* OR (95% CI) |
|
| All participants |
1.41 (0.819–2.427) p=0.215 |
1.24 (0.712–2.174) p=0.443 |
2.30 (1.477–3.592) p<0.001 |
1.96 (1.237–3.117) p=0.004 |
3.83 (2.114–6.950) p<0.001 |
3.35 (1.821–6.166) p<0.001 |
| Men | 1.99 (0.959–4.146) p=0.065 |
1.72 (0.792–3.735) p=0.171 |
3.15 (1.420–7.003) p=0.005 |
2.57 (1.099–5.989) p=0.029 |
3.25 (1.322–8.011) p=0.010 |
3.08 (1.181–8.038) p=0.021 |
| Women | 1.11 (0.423–2.889) p=0.838 |
1.04 (0.389–2.788) p=0.936 |
1.97 (1.155–3.374) p=0.013 |
1.76 (1.008–3.059) p=0.047 |
5.53 (2.351–13.0) p<0.001 |
4.72 (1.973–11.3) p<0.001 |
| Age <70 years |
1.41 (0.448–4.450) p=0.556 |
1.11 (0.344–3.572) p=0.863 |
0.78 (0.220–2.775) p=0.703 |
0.63 (0.171–2.341) p=0.494 |
5.47 (1.502–20.0) p=0.010 |
3.25 (0.811–13.0) p=0.096 |
| Age ≥70 years |
1.10 (0.574–2.093) p=0.780 |
1.07 (0.557–2.065) p=0.835 |
2.25 (1.314–3.844) p=0.003 |
2.14 (1.233–3.715) p=0.007 |
2.30 (1.157–4.581) p=0.018 |
2.37 (1.182–4.762) p=0.015 |
| Black | 1.44 (0.503–4.147) p=0.494 |
1.27 (0.425–3.805) p=0.668 |
1.44 (0.446–4.674) p=0.539 |
1.35 (0.402–4.507) p=0.630 |
7.22 (1.771–29.5) p=0.006 |
6.93 (1.577–30.4) p=0.010 |
| White | 1.54 (0.407–5.815) p=0.525 |
1.76 (0.425–7.276) p=0.436 |
2.00 (0.512–7.813) p=0.319 |
2.58 (0.628–10.6) p=0.189 |
3.75 (0.714–19.7) p=0.118 |
4.93 (0.892–27.2) p=0.067 |
| Hispanic | 1.17 (0.529–2.568) p=0.705 |
1.00 (0.449–2.244) p=0.992 |
2.89 (1.704–4.889) p<0.001 |
2.23 (1.279–3.893) p=0.005 |
2.96 (1.359–6.440) p=0.006 |
2.48 (1.123–5.468) p=0.025 |
| BMI ≥30 kg/m2 |
2.08 (0.749–5.758) p=0.160 |
1.96 (0.689–5.595) p=0.207 |
2.68 (1.162–6.177) p=0.021 |
3.23 (1.276–8.181) p=0.013 |
2.37 (0.658–8.554) p=0.186 |
2.26 (0.606–8.462) p=0.225 |
| BMI <30 kg/m2 |
1.24 (0.649–2.366) p=0.516 |
1.05 (0.537–2.055) p=0.886 |
2.28 (1.341–3.892) p=0.002 |
1.80 (1.035–3.136) p=0.037 |
4.53 (2.271–9.038) p<0.001 |
3.92 (1.928–7.965) p<0.001 |
All comparisons were with normal LV geometry.
*
Adjusted for hypertension, diabetes mellitus, and atrial fibrillation.
BMI = body mass index, CI = confidential interval, LV = left ventricle, OR = odds ratio, and WMHV = white matter hyperintensity volume.