Table 1. Biodistribution of 89Zr-5B1 in Mice Harboring Subcutaneous Capan-2 Xenografts That Were Injected with Cold 5B1 4 h Prior to Injection of the Indicated Amount of Radiotracer; All Values Are Reported as %ID/g.
| 100
μg preloading |
40 μg preloading | 250 μg preloading | ||||
|---|---|---|---|---|---|---|
| organ | 24 h | 48 h | 72 h | 120 h | 120 h | 120 h |
| blood | 12.5 ± 1.5 | 11.0 ± 2.2 | 7.3 ± 1.8 | 4.5 ± 2.2 | 4.7 ± 1.5 | 5.6 ± 1.3 |
| tumor | 23.4 ± 4.6 | 35.6 ± 6.6 | 28.7 ± 9.9 | 44.0 ± 12.3 | 44.1 ± 11.5 | 54.7 ± 25.3 |
| heart | 3.5 ± 0.8 | 3.2 ± 0.5 | 2.1 ± 0.1 | 1.5 ± 0.6 | 1.7 ± 0.5 | 1.8 ± 0.3 |
| lungs | 7.2 ± 2.4 | 5.3 ± 1.3 | 3.4 ± 0.8 | 2.6 ± 1.0 | 3.0 ± 0.8 | 4.2 ± 1.2 |
| liver | 6.8 ± 1.2 | 8.6 ± 2.2 | 9.5 ± 4.1 | 14.3 ± 5.8 | 16.1 ± 6.7 | 13.2 ± 3.1 |
| spleen | 5.0 ± 1.6 | 5.4 ± 1.5 | 3.8 ± 0.7 | 7.9 ± 2.9 | 11.6 ± 7.7 | 7.6 ± 0.5 |
| pancreas | 1.0 ± 0.1 | 1.0 ± 0.1 | 0.8 ± 0.1 | 0.6 ± 0.2 | 0.7 ± 0.1 | 0.8 ± 0.1 |
| stomach | 0.6 ± 0.1 | 0.8 ± 0.2 | 0.7 ± 0.2 | 0.4 ± 0.2 | 0.7 ± 0.2 | 0.7 ± 0.1 |
| small intestine | 1.1 ± 0.1 | 1.0 ± 0.3 | 0.9 ± 0.3 | 0.6 ± 0.3 | 0.7 ± 0.1 | 0.8 ± 0.2 |
| large intestine | 0.7 ± 0.1 | 0.7 ± 0.1 | 0.8 ± 0.2 | 0.5 ± 0.1 | 0.6 ± 0.1 | 0.7 ± 0.2 |
| kidneys | 6.8 ± 3.6 | 5.1 ± 0.4 | 4.8 ± 1.0 | 4.1 ± 1.0 | 4.2 ± 0.3 | 4.7 ± 0.7 |
| muscle | 0.9 ± 0.1 | 0.8 ± 0.2 | 0.7 ± 0.1 | 0.4 ± 0.2 | 0.6 ± 0.2 | 0.6 ± 0.1 |
| bone | 3.8 ± 0.7 | 5.1 ± 0.9 | 4.7 ± 1.9 | 6.6 ± 0.6 | 7.1 ± 0.3 | 8.2 ± 0.9 |