Table 1.
Retinal haemodynamic and cardiovascular variables (CLBF)
| Gas provocation stages | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| (, ) | 40, 38 | 50, 38 | 60, 38 | 80, 38 | 100, 38 | 300, 38 | 500, 38 | 500, 30 | P value |
| SBP (mmHg) | 119.21 (8.06) | 117.45 (9.57) | 117.57 (10.81) | 116.86 (9.83) | 115.93 (8.76) | 118.41 (9.13) | 119.06 (8.97) | 119.02 (8.60) | <0.001 |
| DBP (mmHg) | 71.80 (6.04) | 71.23 (5.23)* | 75.24 (6.15) | 75.84 (7.17) | 75.93 (6.55) | 76.18 (6.10) | 77.35 (5.83) | 77.54 (5.60) | 0.001 |
| HR (beats min−1) | 86.41 (10.33)*** | 78.59 (10.70)*** | 77.22 (11.03)* | 73.09 (9.02) | 72.82 (10.75) | 68.48 (8.34)* | 69.64 (8.25) | 69.6 (9.22) | <0.001 |
| SaO2 (%) | 74.18 (2.54)*** | 82.90 (2.24)*** | 90.93 (2.30)*** | 96.53 (1.53)* | 98.30 (0.95) | 99.29 (0.39) | 99.37 (0.45) | 99.43 (0.41) | <0.001 |
| MAP (mmHg) | 87.60 (5.43) | 86.64 (5.80) | 89.35 (6.84) | 89.52 (7.15) | 89.26 (6.32) | 90.26 (6.09) | 91.26 (5.97) | 91.36 (5.45) | <0.001 |
| (mmHg) | 38.34 (0.38) | 38.12 (0.64) | 38.44 (0.60) | 38.31 (0.48) | 38.12 (0.86) | 38.02 (0.33) | 37.92 (0.65) | 29.31 (0.76)*** | <0.001 |
| (mmHg) | 41.14 (1.40)*** | 49.75 (1.82)*** | 59.39 (1.34)*** | 79.76 (1.86)*** | 101.65 (3.28) | 299.56 (6.05)*** | 494.51 (9.14)*** | 493.54 (19.81)*** | <0.001 |
| Sample size | 10 | 11 | 13 | 13 | 13 | 13 | 13 | 13 | |
| Arteriolar diameter (uM) | 110.64 (15.38)*** | 109.59 (14.56)** | 107.25 (12.98) | 105.76 (12.88) | 104.63 (11.49) | 100.44 (13.86)* | 97.52 (13.27)*** | 96.30 (12.53)*** | <0.001 |
| ∆ % Diameter | 8.53 (7.19)*** | 5.98 (7.21)** | 2.45 (3.24) | 0.97 (2.19) | 0.0 (0.00) | −4.23 (3.94)* | −6.94 (5.23)*** | −8.04 (4.96)*** | <0.001 |
| Arteriolar velocity (mm s−1) | 35.79 (8.14)** | 30.92 (6.87) | 31.62 (9.32) | 31.25 (9.83) | 30.28 (7.66) | 26.42 (9.71) | 20.74 (7.39)*** | 20.38 (6.42)*** | <0.001 |
| ∆ % Velocity | 26.92 (18.85)*** | 4.72 (10.10) | 4.43 (15.62) | 2.83 (18.21) | 0.00 (0.00) | −13.91 (14.76)* | −31.37 (16.29)*** | −34.11 (14.70)*** | <0.001 |
| RBF (μl min−1) | 10.76 (4.41)*** | 9.19 (3.78) | 9.07 (4.34) | 8.65 (4.17) | 8.16 (3.46) | 6.87 (4.27) | 4.93 (2.70)*** | 4.73 (2.43)*** | <0.001 |
| ∆ % Flow | 48.66 (19.02)*** | 17.88 (16.63)* | 9.53 (16.95) | 5.04 (19.82) | 0.00 (0.00) | −20.25 (18.71)** | −40.45 (16.31)*** | −41.71 (15.03)*** | <0.001 |
SBP, systolic blood pressure; DBP, diastolic blood pressure; HR, heart rate; ∆, change. *P < 0.05; **P < 0.01; ***P < 0.001 vs. standardized baseline (100 mmHg , 38 ).