Table 2.

Grade III/IV CTCAE toxicities during treatment.

System organ class	Adverse event	Induction chemotherapy		CRT
		Both arms (n = 85)		OxCapRT (n = 38)		CarPacRT (n = 42)
		n	%	n	%	n	%
Any toxicity		27	31.8	16	42.1	22	52.4
Any haematological toxicity		2	2.4	6	15.8	12	28.6
Blood and lymphatic system disorders	Anaemia	1	1.2	1	2.6	0	0.0
	Febrile neutropenia	0	0	0	0.0	1	2.4
Cardiac	Chest pain	2	4.8	0	0.0	0	0.0
Gastrointestinal	Any in this class	15	17.6	5	13.2	8	19.0
	Abdominal pain	2	2.4	1	2.6	0	0.0
	Colonic spasm	0	0.0	1	2.6	0	0.0
	Constipation	0	0.0	1	2.6	0	0.0
	Diarrhoea	7	8.2	0	0.0	1	2.4
	Dry mouth	1	1.2	1	2.6	0	0.0
	Dysphagia	6	7.1	2	5.3	2	4.8
	GI haemorrhage	0	0.0	0	0.0	1	2.4
	Mucositis	1	1.2	0	0.0	0	0.0
	Nausea/vomiting	6	7.1	0	0.0	0	0.0
	Oesophageal pain	0	0.0	0	0.0	1	2.4
	Oesophagitis	1	1.2	2	5.3	2	4.8
General disorders	Fatigue	9	10.6	4	10.5	6	14.3
Injury	Fall	0	0.0	1	2.6	0	0.0
Investigations	Lymphocyte decrease	0	0.0	3	7.9	3	7.1
	Platelet decrease	1	1.2	1	2.6	0	0.0
	Neutrophil decrease	0	0.0	1	2.6	9	21.4
	White blood cell decrease	0	0.0	2	5.3	2	4.8
Metabolism	Anorexia	2	2.4	2	5.3	0	0.0
	Other	4	4.7	0	0.0	0	0.0
Nervous system	Peripheral neuropathy	5	5.9	0	0.0	0	0.0
	Pharyngolaryngeal dysaesthesia	1	1.2	0	0.0	0	0.0
Respiratory	Dyspnoea	1	1.2	0	0.0	1	2.4
Vascular	Hypertension	1	1.2	1	2.6	0	0.0
	Hypotension	0	0.0	0	0.0	1	2.4
	Peripheral ischaemia	1	1.2	0	0.0	0	0.0
	Thromboembolic events	1	1.2	1	2.6	1	2.4

CTCAE, Common Terminology Criteria for Adverse Events.