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. 2016 Nov 25;8(3):4837–4848. doi: 10.18632/oncotarget.13596

Figure 3. The protective role of APS in doxorubicin-induced cardiomyocyte injury.

Figure 3

A. APS reversed doxorubicin-induced increased LC3B II/I and p62/SQSTM1 and activated of caspase-3 in a concentration-dependent manner in NRVMs, as assayed by Western blots (n = 5, *P < 0.05, **P<0.01 vs. Con group; # P< 0.05,## P<0.01 vs. DOX group). B. Pretreatment of 100 nM rapamycin effectively reversed the APS protective effects in cardiomyocytes, as assessed by Western blots. The NRVMs were pretreated for 1 h with 100 nM rapamycin before APS (50 μg/ml) and DOX (0.5 μM) treatment. (n = 5, *P < 0.05, **P<0.01)