Table 2. Association results for the nine variants with increased PCa risk^a,b.

		FHCRC				PLCO				Combined meta-analysis
		1,265 cases and 1,230 controls				4,222 cases and 2,899 controls				5,487 cases and 4,129 controls
Chr:Position	Variant	Ca/Co Freqc	ORd	95% CIe	P	Ca/Co Freqc	ORd	95% CIe	P	Ca/Co Freqc	ORd	95% CIe	P
1:22923859	EPHA8 p.Pro607His	2.50/0.94	2.70	1.20 – 6.07	0.017	1.82/1.86	0.97	0.69 – 1.39	0.876	1.94/1.65	1.14	0.83 – 1.57	0.420
2:242695399	D2HGDH p.Ala225Thr	2.46/1.06	2.37	1.23 – 4.56	0.010	1.46/1.87	0.80	0.55 – 1.16	0.228	1.69/1.63	1.04	0.75 – 1.43	0.821
3:97868404	OR5H14 p.Met59Val	2.54/1.39	1.85	1.02 – 3.36	0.042	2.42/1.93	1.27	0.92 – 1.78	0.157	2.45/1.77	1.39	1.04 – 1.85	0.026
6:32946119	BRD2 p.Ala605Pro	0.79/0.16	4.99	1.09 – 22.86	0.038	0.62/0.73	0.87	0.49 – 1.57	0.640	0.66/0.56	1.09	0.63 – 1.86	0.765
17:46805705	HOXB13 p.Gly84Glu	1.42/0.25	5.68	1.67 – 19.36	0.005	1.11/0.31	3.78	1.94 – 8.28	0.0003	1.18/0.29	4.20	2.26 – 7.79	5.4×10−6
17:48542714	CHAD p.Ala342Asp	1.43/0.41	3.51	1.30 – 9.49	0.013	1.23/0.97	1.28	0.81 – 2.06	0.292	1.28/0.80	1.53	1.01 – 2.34	0.046
19:11486354	SWSAP1 p.Leu118Ile	2.55/0.98	2.61	1.34 – 5.09	0.005	1.44/1.31	1.12	0.75 – 1.70	0.593	1.70/1.21	1.41	0.99 – 2.00	0.055
22:20024596	TANGO2 p.Ser17Ter	2.77/1.47	1.93	1.08 – 3.42	0.026	2.30/1.66	1.39	0.98 – 1.99	0.065	2.41/1.60	1.52	1.13 – 2.05	0.006
22:50873415	PPP6R2 p.Arg103His	2.07/1.06	2.02	1.03 – 3.96	0.040	1.83/1.66	1.09	0.76 – 1.58	0.636	1.88/1.48	1.26	0.91 – 1.73	0.163

^aAdditional data are in Supplemental Table S4.

^bResults with P < 0.05 are in bold.

^cCase carrier frequency in percent/control carrier frequency in percent.

^dAdjusted for age.

^e95% Confidence Interval.