Table 6. Meta-analysis association results after stratifying by disease aggressiveness^a,b.

Variant	Disease Stratac	Non-carrier	Carrier	Freqd	ORe	95% CIf	P
HOXB13 p.Gly84Glu	Control	4110	12	0.29	1.00		Reference
	Non-aggressive	4347	47	1.07	3.80	2.02 – 7.17	3.62 × 10−5
	Aggressive	1074	18	1.65	5.54	2.71 – 11.32	2.68 × 10−6
TANGO2 p.Ser17Ter	Control	4059	66	1.60	1.00		Reference
	Non-aggressive	4298	97	2.21	1.37	1.00 – 1.89	0.047
	Aggressive	1055	35	3.21	2.06	1.35 – 3.13	0.00075
OR5H14 p.Met59Val	Control	4051	73	1.77	1.00		Reference
	Non-aggressive	4278	111	2.53	1.43	1.06 – 1.93	0.019
	Aggressive	1066	23	2.11	1.23	0.77 – 1.99	0.387
CHAD p.Ala342Asp	Control	4087	33	0.80	1.00		Reference
	Non-aggressive	4336	56	1.28	1.54	1.00 – 2.38	0.049
	Aggressive	1076	14	1.28	1.65	0.89 – 3.08	0.112

^aSupplemental Table S7 has the results for the FHCRC and PLCO studies separately.

^bResults with P < 0.05 are in bold.

^cAggressive disease was defined as Gleason 8-10 or regional/distant stage.

^dCarrier frequency in percent.

^eMeta-analysis of age adjusted polytomous logistic regression data.

^f95% Confidence Interval.