Table 2. Incremental cost-effectiveness of stenting vs. endarterectomy.
| Incremental cost | QALYs gained | Incremental net monetary benefit | Probability stenting cost-effective | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| $29 000 | $43 000 | |||||||||
| Mean | (95% CI) | Mean | (95% CI) | Mean | (95% CI) | Mean | (95% CI) | $29 000 | $43 000 | |
| Base case* | 736 | (-353, 1826) | -0.010 | (-0.117, 0.097) | -991 | (-4475, 2494) | -1118 | (-6110, 3875) | 0.27 | 0.31 |
| No adjustment† | 808 | (-299, 1915) | 0.019 | (-0.098, 0.135) | -215 | (-4027, 3419) | 81 | (-5369, 5299) | 0.43 | 0.49 |
| Complete case analysis‡ | 761 | (-1193, 2715) | 0.006 | (-0.194, 0.206) | -592 | (-6665, 5482) | -507 | (-9333, 8318) | 0.42 | 0.45 |
| Sub-group analyses§ | ||||||||||
| Men | 481 | (-672, 1634) | -0.055 | (-0.185, 0.076) | -2043 | (-6107, 2023) | -2822 | (-8702, 3058) | 0.17 | 0.18 |
| Women | 1123 | (-1153, 3400) | 0.103 | (-0.098, 0.304) | 1793 | (-4759, 8371) | 3270 | (-6044, 12 583) | 0.71 | 0.75 |
| Age ≥70 years | 1112 | (-461, 2685) | -0.061 | (-0.219, 0.097) | -2845 | (-7814, 2126) | -3710 | (-10 859, 3437) | 0.13 | 0.16 |
| Age <70 years | 204 | (-1018, 1426) | 0.057 | (-0.094, 0.208) | 1416 | (-3189, 6023) | 2227 | (-4481, 8935) | 0.73 | 0.75 |
QALY = quality-adjusted life year. CI = confidence interval. Costs are in 2013/14 US$.
Data include values imputed using multiple imputation (see text). The QALYs gained, incremental cost and incremental net monetary benefit figures are for stenting minus endarterectomy and are adjusted for potential confounders (see text).
As for the base case analysis except the QALYs gained and the incremental costs are unadjusted.
As for the base case analysis except there is no multiple imputation of missing values and the 95% confidence intervals were derived from 1000 bootstrap replications of a single dataset containing the N=202 endarterectomy patients and N=254 stenting patients with no missing values.
As for the base case analysis but run on patients within each sub-group. Among the N=857 endarterectomy patients 606 are men, 251 are women, 453 are age ≥70 and 404 are <70. Among the N=853 stenting patients the figures are 601, 252, 458 and 395.