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. 2017 Feb;17(1):12–16. doi: 10.17305/bjbms.2016.1553

FIGURE 1.

FIGURE 1

(A) The effects of DL-2-amino-3-phosphonopropionic acid (DL-AP3) on cell viability in four groups of neuronal cells, measured by CCK-8 kit. DL-AP3 significantly attenuated the inhibitory effect of oxygen-glucose deprivation (OGD) on neuronal viability in OGD + DL-AP3 group. (B) The effects of DL-AP3 on apoptosis in four groups of neuronal cells determined using flow cytometry. OGD significantly increased the apoptotic cell rate in OGD group, but this effect was significantly attenuated in OGD + DL-AP3 group. DL-AP3: DL-2-amino-3-phosphonopropionic acid; OGD: oxygen-glucose deprivation; CCK-8: Cell counting kit-8; Control: Control group; DL-AP3: DL-AP3 group was treated with 10 µM of DL-AP3 for 6 hours; OGD: OGD group in which neurons were cultured under OGD conditions for 12 hours; OGD + DL-AP3: OGD + DL-AP3 group, in which OGD model was first established and then the cells were treated with 10 µM of DL-AP3 for 6 hours; ns: no significance; **p < 0.01; ***p < 0.001.