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. 2017 Feb;175:75–81. doi: 10.1016/j.clim.2016.11.018

Table 3.

Successfully validated somatic mutations in decreasing order of allelic fraction.

Allelic fraction (validation) Allelic fraction (discovery) Sample Gene AA change CADD score
4.63% 4.71% MS-12-CD8 + CD1C R89C 10.0
4.03% 2.71% MS-8-CD19 + TRAF2 409–410 LF/Lb 21.6c
2.88% 2.29% MS-19-CD8 + CD46 A250Tb 23.4c
2.81% 2.70% MS-21-CD8 + RBM6 P24Sb 25.3c
2.71% 2.70% MS-2-CD8 + A2ML1a R1001W 32.0c
2.28% 1.62% MS-1-CD8 + IKZF3 155–156 FT/Sb 22.9c
2.23% 2.14% MS-2-CD8 + BTK Splicingb 24.2c
1.58% 1.69% MS-19-CD8 + PTPMT1 I165Vb 17.0
1.58% 1.29% MG-5-others CD56/NCAM1 G417Rb 34.0c
1.36% 0.70% MS-19-CD8 + ITGA2a Q581K 16.4
1.22% 0.86% MS-21-CD8 + CD56/NCAM1 R358Xb 18.2
1.21% 1.68% MS-8-CD8 + RPA1 L394Pb 25.5c
0.98% 1.32% MS-8-CD8 + KIR3DL2 D392Y 23.4c
0.95% 1.15% MS-21-CD8 + RORA R533Q 23.0c
0.83% 1.23% MS-19-CD8 + PSG1a S23Tb 12.4
0.83% 1.04% MS-3-CD8 + HMMR E405Kb 26.5c
0.80% 1.31% NL-9-CD8 + C6a A298Pb 23.1c
0.68% 0.80% NL-9-CD8 + CLIP2 R932H 34.0c
0.59% 1.07% MS-1-CD8 + MBL2a A37S 8.9
0.46% 0.74% MS-2-CD4 + CD180 D526Yb 24.4c
0.45% 0.70% MS-21-CD8 + STAT3 D661Y 34.0c
0.40% 0.74% MS-22-CD8 + INSRa A119Vb 31.0c
0.35% 0.46% MS-14-CD8 + ITGB3 F229Lb 29.7c
0.32% 0.53% MS-8-CD8 + TLR7a N275Kb 0.009
0.23% 0.60% MS-3-CD8 + MAPK10a S316Fb 22.2c
0.19% 1.34% MS-12-others ATM L2519Vb 26.3c
0.19% 0.56% MS-23-CD8 + CFH V407Lb 0.001

The allelic fraction of a somatic mutation is calculated as the percentage of sequencing reads that contain the variant base. Genomic coordinates are shown in Table S2. Sample code consists of the patient number and a cell population specifier where “others” denotes the CD4 − CD8 − CD19 − population.

The allelic fraction of a somatic mutation is calculated as the percentage of sequencing reads that contain the variant base. Genomic coordinates are shown in Table S2. Sample code consists of the patient number and a cell population specifier where “others” denotes the CD4 − CD8 − CD19 − population.

a

Gene not expressed in the target cell population type based on RNA sequencing data.

b

Indicates a novel mutation.

c

CADD scores of 20 or more can be considered predictably deleterious.