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. 2016 Sep 12;7(41):66468–66479. doi: 10.18632/oncotarget.11979

Figure 7. The CEACAM1-mechanism of action during hMPV infection.

Figure 7

(1) HMPV binds and infects the cells. (2) HMPV RNA is sense by RIG-I, which subsequently activates downstream the phosphorylation of IRF3. (3) IRF3 undergoes conformational changes and dimerization, then translocates to the nucleus and binds the CEACAM1 promoter. (4) CEACAM1 mRNA is transcribed. (5) CEACAM1 is overexpressed on the cell surface of infected cells. (6) The SHP2 phosphatase anchor on CEACAM1 ITIMs and subsequently inhibits the HMPV replication by inhibiting protein production.