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. 2016 Aug 25;7(41):66512–66524. doi: 10.18632/oncotarget.11614

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Copyright: © 2016 Yin et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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(A) CellTiter-Glo^® luminescence assay was applied for detecting the effect of skp2 siRNA in combination with rottlerin treatment on breast cancer cell growth. *P < 0.05, compared with control; ^#P < 0.05 compared with rottlerin treatment or Skp2 siRNA transfection. Control: siRNA control; SiRNA: Skp2 siRNA; Both: rottlerin + Skp2 siRNA. (B) Apoptosis was determined by Flow cytometry in MDA-MB-231 with Skp2 siRNA transfection and rottlerin treatment. (C) Left panel: The wound healing assay was used to investigate the cell migration in breast cancer cells after Skp2 siRNA transfection and rottlerin treatment. Right panel, Quantitative results are illustrated for left panel. *P < 0.05, compared with control; ^#P < 0.05 compared with rottlerin treatment or Skp2 siRNA transfection.