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. 2016 Aug 27;7(41):66540–66557. doi: 10.18632/oncotarget.11658

Figure 7. The IDO1 inhibitor MTH-trp enhances the anti-tumor effect of IFNα in vivo.

Figure 7

Male Balb/cJ mice (n= 37) were injected subcutaneously with 500,000 RENCA cells on day 0. Treatments were initiated on day 7 and mice were euthanized on day 21; MTH-trp (4 mg/mouse) was injected daily (IP); IFNα (25,000U) was injected 5 d/week (SC). A. Resected tumors were measured with calipers and the relative tumor growth rate for each mouse is plotted as size on day 21/size on day 7. Median data points are indicated with a horizontal line. *P < 0.07 compared to Con (control) and MTH. *P < 0.05 compared to IFNα. B. Final weights of resected RENCA tumors. *P < 0.05 compared to IFNα. *P < 0.1 compared to Con. Data are least squares means ± standard error. C. Proteins extracted from Balb/c mouse kidneys or RENCA tumors from control mice or mice treated with MTH-trp, IFNα or IFNα+MTH-trp were probed for IDO1 expression by immunoblotting.