Figure 2. Unbiased, background-corrected, whole genome search of melanoma TCGA data.

a. Flowchart of the search method. b. Model fit to the distribution of 4-scan lengths along chromosome 1. The green line indicates estimated local average 4-scan width; the red line indicates the threshold below which our model deems 4-scans significant (q < 0.01); and the tan-colored line represents the fixed threshold of 15bp used in the initial search. c. Annotated locations of those 4-scans deemed significant by the model. Overlapping significant 4-scans were merged into hotspots. d. Motif discovered by MEME in a proximal promoter hotspots.