Table 2. Clinical and pathologic characteristics of the 12 cases with no ctDNA alterations detected.

Case number	Histology	Stage at Diagnosis	Location of tumor(s)	Small volume disease?	Other pathologic features	On therapy at time of blood draw?
1	Lung Adenocarcinoma	IIIB	Thoracic only	N	None	Y
5	NSCLC	IV	Thoracic only	N	Mucinous	N
6	NSCLC	IA	Thoracic only	Y	None	N
7	NSCLC	IV	Isolated leptomeningeal disease	N	None	N
8	NSCLC	IV	Thoracic only	N	None	Y
9	NSCLC	IIB	Thoracic + brain	Y	Lepidic	Y
10	NSCLC	IIA	Thoracic only	N	Lepidic	N
11	NSCLC	IVB	Bone	Y	None	N
61	NSCLC	IV	Thoracic only	Y	Lepidic	N
70	Lung Squamous Cell Carcinoma	IA	Thoracic only	Y	None	N
73	Lung Adenocarcinoma	IV	Thoracic only	N	Lepidic, mucinous	N
82	Lung Adenocarcinoma	IV	Thoracic only	Y	None	N

NSCLC, non-small cell lung cancer.