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. 2016 Sep 2;7(41):66906–66921. doi: 10.18632/oncotarget.11836

Figure 7. Detection of DNA damage in autopsy samples.

Figure 7

(A) PCR band pattern using control DNA. Lane 1, Intact genomic DNA; Lane 2–4, Genomic DNA sonicated to 500 bp, 300 bp or 150 bp; Lane 5, DNA from a representative frozen autopsy tissue; Lane 6, DNA from a representative formalin-fixed paraffin-embedded (FFPE) tissue sample. (B) Representative PCR band patterns of samples collected from two autopsy cases. In each panel, the first lane is intact genomic DNA and the remaiing lanes correspond to the tissue types shown in (C) Arrows indicate samples with DNA damage. L1, L2, L3, L4 and CL represent locus 1, 2, 3, 4 and control locus, respectively. (C) Relative DNA quality calculated as described in Materials and Methods. Met, metastasis; NL, normal.