Table 1. Clinicopathological features of extranodal metastasis negative and positive groups in this study.
| Clinicopathological features | All patients (n=1457) | TNM I-II stage (n=679, 46.6%) | TNM III stage (n=699, 48.0%) | TNM IV stage (n=79, 5.4%) | ENMP (n=133, 9.1%) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ENMN | ENMP | ENMN | ENMP | ENMN | ENMP | ENMN | ENMP | 1-2 | >2 | |||||||
| n=1324 | n=133 | P value | n=667 | n=12 | P value | n=594 | n=105 | P value | n=63 | n=16 | P value | n=93 | n=40 | P value | ||
| Age (years) | Mean±SD | 56.8±11.7 | 58.6±11.6 | 0.100 | 56.7±12.0 | 65.8±11.6 | 0.010 | 57.2±11.3 | 56.9±11.3 | 0.801 | 54.8±11.7 | 64.4±9.6 | 0.003 | 58.0±12.5 | 59.8±9.1 | 0.409 |
| ≥60 | 576 (43.5) | 66 (49.6) | 0.175 | 292 (43.8) | 9 (75.0) | 0.031 | 264 (44.4) | 44 (41.9) | 0.629 | 20 (31.7) | 13 (81.3) | <0.001 | 45 (48.4) | 21 (52.5) | 0.664 | |
| <60 | 748 (56.5) | 67 (50.4) | 375 (56.2) | 3 (25.0) | 330 (55.6) | 61 (58.1) | 43 (68.3) | 3 (18.8) | 48 (51.6) | 19 (47.5) | ||||||
| Gender | Male | 915 (69.1) | 104 (78.2) | 0.029 | 459 (68.8) | 8 (66.7) | 1.000 | 418 (70.4) | 84 (80.0) | 0.043 | 38 (60.3) | 12 (75.0) | 0.277 | 74 (79.6) | 30 (75.0) | 0.558 |
| Female | 409 (30.9) | 29 (21.8) | 208 (31.2) | 4 (33.3) | 176 (29.6) | 21 (20.0) | 25 (39.7) | 4 (25.0) | 19 (20.4) | 10 (25.0) | ||||||
| Longitudinal location | U | 292 (22.1) | 26 (19.5) | 0.001 | 112 (16.8) | 4 (33.3) | 0.387 | 162 (27.3) | 19 (18.1) | 0.002 | 18 (28.6) | 3 (18.8) | 0.001 | 21 (22.6) | 5 (12.5) | 0.244 |
| M | 273 (20.6) | 32 (24.1) | 120 (18.0) | 1 (8.3) | 137 (23.1) | 28 (26.7) | 16 (25.4) | 3 (18.8) | 22 (23.7) | 10 (25.0) | ||||||
| L | 741 (56.0) | 66 (49.6) | 432 (64.8) | 7 (58.3) | 286 (48.1) | 50 (47.6) | 23 (36.5) | 9 (56.3) | 46 (49.5) | 20 (50.0) | ||||||
| UML | 18 (1.4) | 9 (6.8) | 3 (0.4) | 0 (0.0) | 9 (1.5) | 8 (7.6) | 6 (9.5) | 1 (6.3) | 4 (4.3) | 5 (12.5) | ||||||
| Cross sectional location | Lesser | 710 (53.6) | 72 (54.1) | 0.073 | 363 (54.4) | 6 (50.0) | 0.830 | 316 (53.2) | 59 (56.2) | 0.097 | 31 (49.2) | 7 (43.8) | 0.388 | 49 (52.7) | 23 (57.5) | 0.087 |
| Greater | 118 (8.9) | 12 (9.0) | 72 (10.8) | 2 (16.7) | 42 (7.1) | 10 (9.5) | 4 (6.3) | 0 (0.0) | 12 (12.9) | 0 (0.0) | ||||||
| Anterior | 82 (6.2) | 3 (2.3) | 49 (7.3) | 0 (0.0) | 31 (5.2) | 1 (1.0) | 2 (3.2) | 2 (12.5) | 3 (3.2) | 0 (0.0) | ||||||
| Posterior | 116 (8.8) | 10 (7.5) | 67 (10.0) | 1 (8.3) | 45 (7.6) | 8 (7.6) | 4 (6.3) | 1 (6.3) | 7 (7.5) | 3 (7.5) | ||||||
| Double | 140 (10.6) | 10 (7.5) | 72 (10.8) | 2 (16.7) | 63 (10.6) | 5 (4.8) | 5 (7.9) | 3 (18.8) | 5 (5.4) | 5 (12.5) | ||||||
| Circumference | 158 (11.9) | 26 (19.5) | 44 (6.6) | 1 (8.3) | 97 (16.3) | 22 (21) | 17 (27) | 3 (18.8) | 17 (18.3) | 9 (22.5) | ||||||
| Macroscopic type | Early stage | 212 (16.0) | 2 (1.5) | <0.001 | 205 (30.7) | 0 (0.0) | 0.137 | 6 (1.0) | 2 (1.9) | 0.829 | 1 (1.6) | 0 (0.0) | 0.719 | 2 (2.2) | 0 (0.0) | 0.435 |
| Borrmann I | 51 (3.9) | 7 (5.3) | 35 (5.2) | 1 (8.3) | 12 (2.0) | 5 (4.8) | 4 (6.3) | 1 (6.3) | 7 (7.5) | 0 (0.0) | ||||||
| Borrmann II | 624 (47.1) | 63 (47.4) | 301 (45.1) | 9 (75.0) | 292 (49.2) | 45 (42.9) | 31 (49.2) | 9 (56.3) | 42 (45.2) | 21 (52.5) | ||||||
| Borrmann III | 370 (27.9) | 49 (36.8) | 119 (17.8) | 2 (16.7) | 231 (38.9) | 42 (40) | 20 (31.7) | 5 (31.3) | 34 (36.6) | 15 (37.5) | ||||||
| Borrmann IV | 67 (5.1) | 12 (9.0) | 7 (1.0) | 0 (0.0) | 53 (8.9) | 11 (10.5) | 7 (11.1) | 1 (6.3) | 8 (8.6) | 4 (10.0) | ||||||
| Differentiation grade | Well | 43 (3.2) | 0 (0.0) | <0.001 | 43 (6.4) | 0 (0.0) | 0.237 | 0 (0.0) | 0 (0.0) | 0.013 | 0 (0.0) | 0 (0.0) | 0.683 | 0 (0.0) | 0 (0.0) | 0.929 |
| Moderately | 246 (18.6) | 7 (5.3) | 169 (25.3) | 2 (16.7) | 71 (12.0) | 4 (3.8) | 6 (9.5) | 1 (6.3) | 5 (5.4) | 2 (5.0) | ||||||
| Poorly | 1035 (78.2) | 126 (94.7) | 455 (68.2) | 10 (83.3) | 523 (88.0) | 101 (96.2) | 57 (90.5) | 15 (93.8) | 88 (94.6) | 38 (95.0) | ||||||
| Tumor size (cm) | Mean±SD | 4.7±2.7 | 6.6±2.6 | <0.001 | 3.5±2.0 | 5.5±2.2 | 0.001 | 5.8±2.6 | 6.7±2.7 | <0.001 | 7.1±4.0 | 6.5±2.6 | 0.555 | 6.1±2.5 | 7.8±2.7 | 0.001 |
| <2.5 | 237 (17.9) | 1 (0.8) | <0.001 | 212 (31.8) | 1 (8.3) | 0.009 | 23 (3.9) | 0 (0.0) | <0.001 | 2 (3.2) | 0 (0.0) | 0.593 | 1 (1.1) | 0 (0.0) | 0.002 | |
| 2.5-5 | 476 (36.0) | 27 (20.3) | 291 (43.6) | 4 (33.3) | 171 (28.8) | 20 (19) | 14 (22.2) | 3 (18.8) | 22 (23.7) | 5 (12.5) | ||||||
| 5-8 | 437 (33.0) | 62 (46.6) | 125 (18.7) | 5 (41.7) | 286 (48.1) | 50 (47.6) | 26 (41.3) | 7 (43.8) | 48 (51.6) | 14 (35.0) | ||||||
| ≥8 | 174 (13.1) | 43 (32.3) | 39 (5.8) | 2 (16.7) | 114 (19.2) | 35 (33.3) | 21 (33.3) | 6 (37.5) | 22 (23.7) | 21 (52.5) | ||||||
| Vessels/nerves invasion | Negative | 1081 (81.6) | 92 (69.2) | 0.001 | 602 (90.3) | 11 (91.7) | 0.870 | 436 (73.4) | 73 (69.5) | 0.410 | 43 (68.3) | 8 (50.0) | 0.173 | 64 (68.8) | 28 (70.0) | 0.893 |
| Positive | 243 (18.4) | 41 (30.8) | 65 (9.7) | 1 (8.3) | 158 (26.6) | 32 (30.5) | 20 (31.7) | 8 (50.0) | 29 (31.2) | 12 (30.0) | ||||||
| T stage | 1a | 174 (13.1) | 0 (0.0) | <0.001 | 174 (26.1) | 0 (0.0) | <0.001 | 0 (0.0) | 0 (0.0) | 0.292 | 0 (0.0) | 0 (0.0) | 0.163 | 0 (0.0) | 0 (0.0) | 0.564 |
| 1b | 157 (11.9) | 0 (0.0) | 156 (23.4) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 1 (1.6) | 0 (0.0) | 0 (0.0) | 0 (0.0) | ||||||
| 2a | 104 (7.9) | 3 (2.3) | 93 (13.9) | 1 (8.3) | 11 (1.9) | 2 (1.9) | 0 (0.0) | 0 (0.0) | 2 (2.2) | 1 (2.5) | ||||||
| 2b | 91 (6.9) | 5 (3.8) | 72 (10.8) | 3 (25.0) | 19 (3.2) | 1 (1.0) | 0 (0.0) | 1 (6.3) | 4 (4.3) | 1 (2.5) | ||||||
| 3 | 115 (8.7) | 12 (9.0) | 64 (9.6) | 3 (25.0) | 50 (8.4) | 8 (7.6) | 1 (1.6) | 1 (6.3) | 8 (8.6) | 4 (10.0) | ||||||
| 4a | 593 (44.8) | 95 (71.4) | 108 (16.2) | 5 (41.7) | 444 (74.7) | 79 (75.2) | 41 (65.1) | 11 (68.8) | 68 (73.1) | 27 (67.5) | ||||||
| 4b | 90 (6.8) | 18 (13.5) | 0 (0.0) | 0 (0.0) | 70 (11.8) | 15 (14.3) | 20 (31.7) | 3 (18.8) | 11 (11.8) | 7 (17.5) | ||||||
| N stage | 0 | 501 (37.8) | 8 (6.0) | <0.001 | 494 (74.1) | 8 (66.7) | 0.572 | 5 (0.8) | 0 (0.0) | 0.008 | 2 (3.2) | 0 (0.0) | 0.469 | 6 (6.5) | 2 (5.0) | 0.016 |
| 1 | 231 (17.4) | 13 (9.8) | 130 (19.5) | 3 (25.0) | 99 (16.7) | 9 (8.6) | 2 (3.2) | 1 (6.3) | 11 (11.8) | 2 (5.0) | ||||||
| 2 | 211 (15.9) | 29 (21.8) | 34 (5.1) | 1 (8.3) | 172 (29.0) | 25 (23.8) | 5 (7.9) | 3 (18.8) | 20 (21.5) | 9 (22.5) | ||||||
| 3a | 251 (19.0) | 56 (42.1) | 8 (1.2) | 0 (0.0) | 220 (37.0) | 50 (47.6) | 23 (36.5) | 6 (37.5) | 45 (48.4) | 11 (27.5) | ||||||
| 3b | 130 (9.8) | 27 (20.3) | 1 (0.1) | 0 (0.0) | 98 (16.5) | 21 (20.0) | 31 (49.2) | 6 (37.5) | 11 (11.8) | 16 (40.0) | ||||||
| M stage | 0 | 1261 (95.2) | 117 (88.0) | <0.001 | 667 (100.0) | 12 (100.0) | — | 594 (100.0) | 105 (100.0) | — | 0 (0.0) | 0 (0.0) | — | 83 (89.2) | 34 (85.0) | 0.492 |
| 1 | 63 (4.8) | 16 (12.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 63 (100) | 16 (100) | 10 (10.8) | 6 (15.0) | ||||||
| TNM stage | IA | 260 (19.6) | 0 (0.0) | <0.001 | 260 (39.0) | 0 (0.0) | 0.001 | 0 (0.0) | 0 (0.0) | 0.003 | 0 (0.0) | 0 (0.0) | — | 0 (0.0) | 0 (0.0) | 0.139 |
| IB | 145 (11.0) | 2 (1.5) | 145 (21.7) | 2 (16.7) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 1 (1.1) | 1 (2.5) | ||||||
| IIA | 89 (6.7) | 2 (1.5) | 89 (13.3) | 2 (16.7) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 2 (2.2) | 0 (0.0) | ||||||
| IIB | 173 (13.1) | 8 (6.0) | 173 (25.9) | 8 (66.7) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 6 (6.5) | 2 (5.0) | ||||||
| IIIA | 151 (11.4) | 15 (11.3) | 0 (0.0) | 0 (0.0) | 151 (25.4) | 15 (14.3) | 0 (0.0) | 0 (0.0) | 13 (14.0) | 2 (5.0) | ||||||
| IIIB | 163 (12.3) | 25 (18.8) | 0 (0.0) | 0 (0.0) | 163 (27.4) | 25 (23.8) | 0 (0.0) | 0 (0.0) | 18 (19.4) | 7 (17.5) | ||||||
| IIIC | 280 (21.1) | 65 (48.9) | 0 (0.0) | 0 (0.0) | 280 (47.1) | 65 (61.9) | 0 (0.0) | 0 (0.0) | 43 (46.2) | 22 (55.0) | ||||||
| IV | 63 (4.8) | 16 (12.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 63 (100) | 16 (100) | 10 (10.8) | 6 (15.0) | ||||||
Abbreviations: SD: standard deviation; ENMN: extranodal metastasis negative; ENMP: extranodal metastasis positive.