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. 2016 Aug 24;7(41):67166–67174. doi: 10.18632/oncotarget.11568

Figure 3. H22(scFv)-MAP is cytotoxic towards CD64+ leukemic blasts ex vivo.

Figure 3

A. Quantitative analysis of the dot blots in Figure 2 representing the proportion of cells undergoing apoptosis (the sum of early (Annexin V+/PI−) and late (Annexin V+/PI+) apoptotic cells) in the different experimental groups. Values are presented as box and whiskers plots with the interquartile range and minimum/maximum values indicated by the error bars. Each measurement was taken in duplicate. Statistical analysis was carried out using the non-parametric one-way ANOVA test (Kruskal-Wallis test by ranks): *p ≤ 0.05. B. Cytotoxicity of H22(scFv)-MAP plotted against its binding activity on leukemic blasts. C. Correlation between the cytotoxicity of the CD64-targeting fusion proteins. Abbreviations: MFI, mean fluorescence intensity.