Figure 7. The combination of PD0325901 and BKM120 is significantly more effective than each single agent in suppressing the growth of NSCLC xenografts A and B.

without apparent toxicity in mice C. A, A549 xenografts were treated (once a day) with vehicle control, PD0325901, BMK120 and their combination (PD+BKM) starting on the same day after grouping. Tumor sizes (A) and mouse body weights (C) were measured as indicated. Each measurement is mean ± SEM (n = 6). After 19 days, the mice were sacrificed and the tumors were removed and weighed (B). *P < 0.05, **P < 0.01, compared with all other three treatment groups.