Figure 4. miR-203 modulates EMT and tumor stemness signals and directly targets ZEB2.
A. Ectopic expression of miR-203 markedly modulated the expression of EMT and tumor stemness factors including suppressing ZEB2, N-cadherin, NANOG, and c-MYC, and BMI1 and induced E-cadherin expression in 5-8F and 6-10B cells. B. Inhibitor of miR-203 restored the expression of ZEB2. C. Luciferase reporter assay demonstrating that ZEB2 is a direct target of miR-203 in NPC (*P<0.05).