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. 2016 Aug 30;7(41):67302–67313. doi: 10.18632/oncotarget.11693

Table 3. Radiomic features according to the number of histologic subtypes within a tumor.

Non-contrast images p Iodine-contrast images p
One subtype Two subtypes Three or four subtypes One subtype Two subtypes Three or four subtypes
Physical features
 Volume (cm3) 6.97±2.14 8.29±2.81 7.93±5.900 0.966 7.08±12.62 4.67±5.85 6.50±5.10 0.432
 Density (HU) 0.57±0.23 0.566±0.22 0.75±0.155 0.008* 1.17±0.016 1.16±0.019 1.17±0.01 0.618
 Mass (g) 5.30±10.35 4.572±9.00 6.00±4.484 0.832 8.25±14.71 5.44±6.78 7.61±5.95 0.426
 Size (mm) 23.11±16.86 21.02±9.26 24.41±10.89 0.488 12.44±18.26 9.83±12.02 17.18±8.85 0.130
Histogram features
 Skewness −0.21±0.66 0.012±0.721 −0.489±0.616 0.037* 0.461±0.822 0.782±1.04 0.056±0.598 0.024*
 Kurtosis 2.75±0.96 2.76±1.01 2.47±1.108 0.598 4.39±2.32 5.60±4.33 4.51±3.29 0.377
 2.5th percentile (HU) −797.76±71.95 −814.99±70.14 −769.28 ±74.37 0.080 -21.07±14.38 -23.42±16.68 -31.39 ±14.34 0.131
 25th percentile (HU) −576.08±193.86 −604.91±181.72 −484.64 ±181.10 0.078 25.31±13.29 21.15±16.143 26.20±15.66 0.397
 50th percentile (HU) −431.21±232.06 −450.78±234.06 −251.37 ±171.56 0.009* 52.50±16.20 47.94±19.68 56.62±5.35 0.220
 75th percentile (HU) -316.05±241.84 -305.18±232.75 -91.90±127.34 0.003* 79.94±17.36 76.38±22.41 83.68±16.05 0.429
 97.5th percentile (HU) -181.87±241.84 -128.25±189.22 32.48±39.52 0.002* 152.31±39.92 156.08±35.30 143.65±27.89 0.464
Regional features
 Uniformity 0.003±0.002 0.002±0.001 0.002±0.001 0.042* 0.009±0.002 0.009±0.002 0.008±0.002 0.365
 Entropy 8.76±0.73 9.08±0.50 9.41±0.37 0.003* 7.17±0.37 7.24±0.32 7.36± 0.31 0.258
 Intensity variability 7.56±3.71 8.49±3.8 9.57±3.53 0.294 7.27±3.18 6.1563.29 8.03±3.27 0.099
 Size-zone variability 13.14±12.21 15.33±11.86 18.59±7.81 0.367 14.42±14.94 14.22±9.44 17.99±8.60 0.454
Local features
 Energy on 1 voxel distance 0.040±0.050 0.034±0.033 0.051±0.067 0.410 0.037±0.017 0.046±0.030 0.049±0.036 0.394
 Energy on 2 voxel distance 0.036±0.046 0.027±0.028 0.042± 0.064 0.356 0.033±0.014 0.040±0.025 0.043± 0.033 0.493
 Energy on 3 voxel distance 0.031±0.025 0.024±0.026 0.039± 0.061 0.337 0.036±0.014 0.040±0.025 0.042± 0.033 0.784
 Entropy on 1 voxel distance 1.74±0.23 1.79±0.19 1.76± 0.24 0.580 1.65±0.15 1.62±0.18 1.59±0.22 0.697
 Entropy on 2 voxel distance 1.82±0.24 1.91±0.20 1.89±0.26 0.306 1.66±0.13 1.66±0.17 1.63± 0.22 0.869
 Entropy on 3 voxel distance 1.81±0.22 1.93±0.22 1.92± 0.28 0.128 1.62±0.15 1.65±0.16 1.63±0.22 0.798
 Correlation on 1 voxel distance 0.089±0.037 0.091±0.046 0.079± 0.036 0.658 0.109±0.062 0.121±0.059 0.154±0.14 0.231
 Correlation on 2 voxel distance 0.047±0.030 0.053±0.024 0.056±0.027 0.555 0.034±0.027 0.036±0.023 0.052±0.057 0.190
 Correlation on 3 voxel distance 0.025±0.038 0.030±0.019 0.040± 0.020 0.231 0.021±0.019 0.017±0.015 0.027±0.030 0.203
 Contrast on 1 voxel distance 5.30±2.23 4.76±2.04 4.47±1.90 0.478 5.51±2.83 4.98±3.13 4.32±2.06 0.492
 Contrast on 2 voxel distance 11.16±4.60 10.45±4.24 10.62±5.01 0.834 8.13±4.25 7.29±3.87 6.09± 2.88 0.290
 Contrast on 3 voxel distance 14.71±6.75 14.29±5.67 15.48± 8.17 0.807 8.62±4.36 7.94±4.19 6.38± 2.86 0.248
 Variance on 1 voxel distance 0.17±0.11 0.163±0.054 0.129± 0.029 0.114 0.176±0.053 0.185±0.052 0.175±0.054 0.704
 Variance on 2 voxel distance 0.17±0.10 0.161±0.054 0.129± 0.032 0.121 0.177±0.052 0.186±0.051 0.177± 0.056 0.718
 Variance on 3 voxel distance 0.16±0.06 0.162±0.054 0.131± 0.038 0.111 0.179±0.050 0.188±0.051 0.179± 0.058 0.765
 Sum mean on 1 voxel distance 8.83±3.47 9.60±3.41 11.544±3.509 0.061 4.37±4.05 4.05±1.92 3.48±1.43 0.351
 Sum mean on 2 voxel distance 8.90±3.51 9.68±3.48 11.354± 3.407 0.111 4.37±1.92 4.02±1.87 3.40±1.46 0.285
 Sum mean on 3 voxel distance 8.46±3.06 9.79±3.57 11.369± 3.468 0.051 4.27±1.75 4.02±1.77 3.36± 1.44 0.267
 Inertia on 1 voxel distance 8.37±2.23 8.43±2.28 10.057± 1.532 0.027* 6.87±1.71 6.50±1.64 6.85±1.71 0.617
 Inertia on 2 voxel distance 8.45±2.26 8.54±2.31 10.20±1.54 0.024* 6.82±1.66 6.47±1.60 6.82± 1.70 0.621
 Inertia on 3 voxel distance 8.39±2.26 8.54±2.31 10.247± 1.554 0.018* 6.70±1.56 6.44±1.56 6.78± 1.69 0.672
 Cluster shade on 1 voxel distance 5.30±2.23 4.76±2.04 4.479±1.903 0.478 5.51±2.83 4.98±3.13 4.33±2.07 0.492
 Cluster shade on 2 voxel distance 11.16±4.60 10.43±4.24 10.629±5.011 0.834 8.14±4.26 7.30±5.68 6.10±2.88 0.290
 Cluster shade on 3 voxel distance 14.71±6.75 14.29±5.67 15.480± 8.177 0.807 8.62±4.37 7.941±3.87 6.38± 2.86 0.248
 Cluster tendency on 1 voxel distance −43.74±16.58 −42.39±50.95 −108.582±29.33 0.244 14.25±29.92 14.76±27.81 3.07±20.57 0.309
 Cluster tendency on 2 voxel distance -37.71±86.04 -36.77±116.02 -82.633± 04.72 0.318 7.57±18.33 8.30±16.88 1.58±15.04 0.374
 Cluster tendency on 3 voxel distance −33.78±64.46 −32.49±95.11 −70.196±88.10 0.314 7.34±15.93 6.95±13.80 1.56± 14.53 0.388
 Homogeneity on 1 voxel distance 4532.07±1777.15 3387.64±2166.78 2629.69±181.00 0.025* 629.72±389.37 565.77±348.42 386.11± 232.51 0.094
 Homogeneity on 2 voxel distance 3480.25± 1460.08 2523.03±1782.39 1899.41±1225.18 0.023* 375.41±229.52 341.68±234.28 243.52± 173.64 0.197
 Homogeneity on 3 voxel distance 2895.88±1303.93 2039.34±1521.84 1380.43±1060.43 0.008* 314.92±192.11 289.38±191.10 215.53± 177.30 0.273
 Maximum probability on 1 voxel distance 0.109±0.110 0.092±0.079 0.137± 0.125 0.248 0.085±0.041 0.110±0.064 0.116± 0.067 0.230
 Maximum probability on 2 voxel distance 0.095±0.102 0.072±0.071 0.117± 0.123 0.189 0.076±0.033 0.095±0.055 0.101± 0.062 0.308
 Maximum probability on 3 voxel distance 0.081±0.0619 0.064±0.065 0.107± 0.120 0.154 0.078±0.029 0.092±0.051 0.096± 0.061 0.491
 Inverse variance on 1 voxel distance 0.381±0.063 0.402±0.045 0.381± 0.051 0.153 0.413±0.050 0.417±0.045 0.416±0.031 0.952
 Inverse variance on 2 voxel distance 0.316±0.060 0.339±0.049 0.322± 0.047 0.185 0.377±0.066 0.386±0.054 0.396±0.046 0.598
 Inverse variance on 3 voxel distance 0.294±0.055 0.305±0.051 0.289± 0.049 0.487 0.372±0.059 0.375±0.056 0.390±0.047 0.558

Features showing uniform tendency are expressed in bold font.

*

P < 0.05