Table 1. Comparison of demographic and clinical characteristics between different age groups of Hodgkin lymphoma (HL) patients.

Characteristics [Ref]	Pediatric HL	AYA (Adolescent and young adult) HL	Adult HL
Age	0-14	15-34	>35
Prevalence [13]	6/million/yr	32/million/yr	28/million/yr
Predominant gender [13, 149]	Male	Female (15-19), Male (<20)	Male (common: 55-74 yr)
Histology [16]	Mixed-cellularity Hodgkin lymphoma (22%)	Nodular sclerosis Hodgkin lymphoma (76%)	Nodular sclerosis Hodgkin lymphoma (61%)
Predominant stage at Diagnosis [16]	II	II	II
Most common symptoms [16, 150]	Painless adenopathy involving supraclavicular or cervical area (80%)	Asymptomatic mediastinal disease	Asymptomatic lymphadenopathy (<80%), B symptoms (40%), Intermittent fever (35%)
EBV association [151]	Yes (<10yr: 80%)	No (<30%)	No (20-50 yr), Yes (>60yr; 70%)
Treatment outcome (5 yr OSa) [16, 149]	90-95%	90%	85.90%

^aOS, Overall Survival