Table 2. Predicted hallmarks and modes of biological interaction.
| Partner 1 | Partner 2 | Direct binding | Linear pathway | Convergence |
|---|---|---|---|---|
| Genome instability hallmark | ||||
| OGG1 | XRCC1 | Synergistic and Co-suppressivea | ||
| PARP1 | XRCC1 | Synergistic | ||
| XPA | XPC | Synergistic | ||
| TP53 | MDM2 | Synergistic | ||
| TGFBR1 | SMAD7 | Suppressiveb | ||
| MUTYH | OGG1 | Synergistic | ||
| MUTYH | XRCC1 | Synergistic | ||
| ADH1B | ALDH2 | Synergistic | ||
| NQO1 | NQO2 | Synergistic | ||
| CYP1A1 | CYP2E1 | Synergistic | ||
| GSTT1 | APEX1 | Redundant | ||
| GSTT1/GSTM1 | APEX1 | Suppressive | ||
| GSTM1 | NAT2 | Redundant | ||
| Proliferation hallmark | ||||
| RPS6KB1 | PRKAG2 | Synergistic | ||
| RPS6KB1 | PIK3CA | Suppressive | ||
| CDKN1B | CHEK2 | Synergistic | ||
| Multiple hallmarksc | ||||
| MMP2 | PARP1 | Suppressive |
a
An OGG1 SNP showed a synergistic interaction with p.Arg399Gln SNP (rs25487) but a co-suppressive interaction with p.Arg194Trp SNP (rs1799782) of XRCC1 [9].
b
The interaction was suppressive with the adjusted ORcombined, but redundant with the crude ORcombined [69].
c
Multiple hallmarks include inflammation, proliferation, insensitivity, resistance, immortality and angiogenesis for MMP2, and mutation for PARP1.