Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Jan 19;8(1):53–58. doi: 10.1080/19490976.2016.1270810

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2017 The Author(s). Published with license by Taylor & Francis

This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.

PMC Copyright notice

Figure 1. — Bacterial profiles and functional dysbiosis mirror ileitis severity in TNF^ΔARE mice. (A) Independently from the litter of origin, SPF TNF^ΔARE mice housed in the same cage display a gradient of ileitis severity, ranging from not diseased (i.e., NR), low inflamed (i.e., lowR) and highly inflamed (R) (adapted from¹); and inflammation correlates to dysbiosis development in this mouse model. (B) β-diversity analysis shows separation of responder TNF^ΔARE mice (R) and low-responders (lowR), non-responders (NR) and WT littermate, all mice are 18 weeks of age (adapted from¹). (C) Lack of early changes in microbiota phylogeny and dysbiosis in SPF TNF^ΔARE mice. Non-parametrical multiple dimensional scaling (NMDS) analysis displaying phylogenetic distances between fecal bacterial communities of 4-week old TNF^ΔARE mice including mice that later in life develop severe (R), intermediate (lowR) and no disease (NR) (adapted from¹).