Table 1a.

GSRS total scores by treatment group and study period.

	Group of randomization
Gastrointestinal Symptom Rating Scale - Scores	Group 1 Sb (N = 13)	Group 2 AC (N = 12)	Group 3 Sb + AC (N = 12)	Group 4 Control (N = 12)	Total (N = 49)
Gastrointestinal symptoms total score D-7 to D0
Missing	0	0	0	12	12
N	13	12	12	0	37
Mean ( ± SD)	18.7 ( ± 5.4)	18.7 ( ± 3.8)	17.3 ( ± 2.4)	NA ( ± NA)	18.2 ( ± 4.0)
Min-Max	[15.0;35.0]	[15.0;26.0]	[15.0;22.0]	[NA; NA]	[15.0;35.0]
Gastrointestinal symptoms total score D0 to D7
Missing	0	0	0	0	0
N	13	12	12	12	49
Mean ( ± SD)	23.2 ( ± 8.8)	26.9 ( ± 14.2)	18.1 ( ± 3.0)	19.3 ( ± 8.1)	21.9 ( ± 9.7)
Min-Max	[15.0;44.0]	[15.0;59.0]	[15.0;25.0]	[15.0;43.0]	[15.0;59.0]
Gastrointestinal symptoms total score D7 to D14
Missing	1	1	0	0	2
N	12	11	12	12	47
Mean ( ± SD)	19.3 ( ± 5.1)	20.3 ( ± 5.9)	16.8 ( ± 1.6)	16.4 ( ± 2.7)	18.1 ( ± 4.3)
Min-Max	[15.0;29.0]	[15.0;34.0]	[15.0;20.0]	[15.0;23.0]	[15.0;34.0]
Gastrointestinal symptoms total score D14 to D21
Missing	1	1	0	0	2
N	12	11	12	12	47
Mean ( ± SD)	19.3 ( ± 5.7)	18.4 ( ± 5.8)	16.5 ( ± 2.9)	15.8 ( ± 2.3)	17.5 ( ± 4.5)
Min-Max	[15.0;33.0]	[15.0;34.0]	[15.0;25.0]	[15.0;23.0]	[15.0;34.0]