Table 1. Cox multivariate regression in high-grade astrocytomas for patients included in the screening cohort (n = 86).

Variables	n	HR (95% CI)	p-value
Gender (female vs male)	48/38	1.07 (0.68-1.69)	0.76
Age	86	1.03 (1.01-1.05	0.0038*
Performance status (KPS ≥80 vs <80)	71/15	0.94 (0.52-1.68)	0.83
Surgery (resection vs biopsy)	81/5	1.20 (0.43-3.37)	0.72
Malignancy grade (WHO III vs IV)	19/67	0.66 (0.35-1.23)	0.19
IDH1 (mutation vs no mutation)	15/71	0.76 (0.38-1.52)	0.44
PROX1 protein (<50%; 50-90%; >90%)	8/41/37	1.12 (0.76-1.67)	0.56

HR= hazard ratio; CI = confidence interval;

^*p ≤ 0.05