Table 2a. Multivariate Cox regression in primary glioblastomas for patients 60 years and older (n = 174).
| First line Treatment Variables | Standard RT (n = 49) | Hypo RT (n = 58) | TMZ (n = 67) | HR# (95% CI) | p -value |
|---|---|---|---|---|---|
| Gender (female vs male) | 14/35 | 32/26 | 25/42 | 0.79 (0.54-1.15) | 0.22 |
| Age (60-70 vs > 70) | 34/15 | 34/24 | 36/31 | 1.08 (0.75-1.55) | 0.68 |
| WHO Performance Status (0-1 vs 2-3) | 36/13 | 48/10 | 51/16 | 0.52 (0.33-0.81) | 0.004* |
| Surgery type (resection vs biopsy) | 44/5 | 54/4 | 60/7 | 0.57 (0.30-1.08) | 0.08 |
| Taking steroids at baseline (no vs yes) | 23/25 (1 m) | 31/27 | 35/31 (1 m) | 0.51 (0.35-0.74) | 0.0004* |
| Radiotherapy (standard + hypo vs TMZ) | 107 | 67 | 0.92 (0.64-1.32) | 0.65 | |
| MGMT status (methyl vs unmethyl) | 15/29 (5 m) | 25/25 (8 m) | 22/36 (9 m) | 0.69 (0.48-0.99) | 0.047* |
| PROX1 protein (<50%; 50-90%; >90%) | 15/12/20 (2 m) | 10/11/33 (4 m) | 16/22/25 (4 m) | 0.89 (0.71-1.10) | 0.28 |
HR= hazard ratio; CI = confidence interval; m = missing data
#
n = 141 patients in the multivariate analysis;
*
p ≤ 0.05